2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”

news Oct 06, 2021 0 391
ugochukwu Franklin Amadike @ugochukwu
2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2021 Nobel Prize in Chemistry to Benjamin List and David W.C. MacMillan “for the development of asymmetric organocatalysis.”

Building molecules is a difficult art. Benjamin List and David MacMillan are awarded the Nobel Prize in Chemistry 2021 for their development of a precise new tool for molecular construction: organocatalysis. This has had a great impact on pharmaceutical research, and has made chemistry greener.

Many research areas and industries are dependent on chemists’ ability to construct molecules that can form elastic and durable materials, store energy in batteries or inhibit the progression of diseases. This work requires catalysts, which are substances that control and accelerate chemical reactions, without becoming part of the final product. For example, catalysts in cars transform toxic substances in exhaust fumes to harmless molecules. Our bodies also contain thousands of catalysts in the form of enzymes, which chisel out the molecules necessary for life.

Catalysts are thus fundamental tools for chemists, but researchers long believed that there were, in principle, just two types of catalysts available: metals and enzymes. Benjamin List and David MacMillan are awarded the Nobel Prize in Chemistry 2021 because in 2000 they, independent of each other, developed a third type of catalysis. It is called asymmetric organocatalysis and builds upon small organic molecules.

The rapid expansion in the use of organic catalysts is primarily due to their ability to drive asymmetric catalysis. When molecules are being built, situations often occur where two different molecules can form, which – just like our hands – are each other’s mirror image. Chemists will often only want one of these, particularly when producing pharmaceuticals.

Organocatalysis has developed at an astounding speed since 2000. Benjamin List and David MacMillan remain leaders in the field, and have shown that organic catalysts can be used to drive multitudes of chemical reactions. Using these reactions, researchers can now more efficiently construct anything from new pharmaceuticals to molecules that can capture light in solar cells. In this way, organocatalysts are bringing the greatest benefit to humankind.

Learn more
Press release: https://bit.ly/3nALTUp
Popular information: https://bit.ly/3nAM0PP
Advanced information: https://bit.ly/3tJb2NA

Franklin Amadike Franklin Amadike Oct 06, 2021
This year’s chemistry laureate Benjamin List had an out-of-the-box question: do amino acids have to be part of an enzyme in order to catalyse a chemical reaction? Or could a single amino acid, or other similar simple molecules, do the same job?

He knew that there was research from the early 1970s where an amino acid called proline had been used as a catalyst – but that was more than 25 years ago. Surely, if proline really had been an effective catalyst, someone would have continued working on it?

This is more or less what List thought; he assumed that the reason why no one had continued studying the phenomenon was that it had not worked particularly well. Without any real expectations, he tested whether proline could catalyse an aldol reaction, in which carbon atoms from two different molecules are bonded together. It was a simple attempt that, amazingly, worked straight away.

With his experiments, List not only demonstrated that proline is an efficient catalyst, but also that this amino acid can drive asymmetric catalysis. Of the two possible mirror images, it was much more common for one of them to form than the other.

Unlike the researchers who had previously tested proline as a catalyst, List understood the enormous potential it could have. Compared to both metals and enzymes, proline is a dream tool for chemists. It is a very simple, cheap and environmentally-friendly molecule. When he published his discovery in February 2000, List described asymmetric catalysis with organic molecules as a new concept with many opportunities: “The design and screening of these catalysts is one of our future aims”.

Read more about this story behind this year’s Nobel Prize in Chemistry:
https://bit.ly/3nAM0PP Re: 2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”
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Franklin Amadike Franklin Amadike Oct 06, 2021
Greetings from Amsterdam!

New chemistry laureate Benjamin List sent us this selfie of him and his wife Dr Sabine List on holiday right after they found out the news about his #NobelPrize.

Stay tuned for our interview with him coming soon! Re: 2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”
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Franklin Amadike Franklin Amadike Oct 06, 2021
The discovery being awarded the Nobel Prize in Chemistry 2021 has taken molecular construction to an entirely new level. It has not only made chemistry greener, but also made it much easier to produce asymmetric molecules.

During chemical construction a situation often arises in which two molecules can form, which – just like our hands – are each other’s mirror image (see figure). Chemists often just want one of these mirror images, particularly when producing pharmaceuticals, but it has been difficult to find efficient methods for doing this. The concept developed by Benjamin List and David MacMillan – asymmetric organocatalysis – is as simple as it is brilliant.

The Royal Swedish Academy of Sciences has decided to award the 2021 Nobel Prize in Chemistry to Benjamin List and David W.C. MacMillan “for the development of asymmetric organocatalysis.”

Learn more
Press release: https://bit.ly/3nALTUp
Popular information: https://bit.ly/3nAM0PP
Advanced information: https://bit.ly/3tJb2NA Re: 2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”
..
Franklin Amadike Franklin Amadike Oct 06, 2021
"I always like to go to the extremes. Can we do things that were just impossible before?"

- 2021 chemistry laureate Benjamin List talks about his future research at this morning's #NobelPrize press conference. Re: 2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”
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Franklin Amadike Franklin Amadike Oct 06, 2021
Re: 2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”
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Franklin Amadike Franklin Amadike Oct 07, 2021
David W.C. MacMillan, awarded this year’s #NobelPrize in Chemistry, was born in 1968 in Bellshill, UK.

He is a professor at Princeton University, USA.

https://chemistry.princeton.edu/faculty/david-macmillan Re: 2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”
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Franklin Amadike Franklin Amadike Oct 07, 2021
This year’s Nobel Prize laureate in chemistry Benjamin List was born in 1968 in Frankfurt, Germany.

He is Director of the Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany.

https://www.kofo.mpg.de/person/100093/219043 Re: 2021 Nobel Prize In Chemistry Awarded To Benjamin List And David W.C. MacMillan “for The Development Of Asymmetric Organocatalysis.”
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